Review





Similar Products

ccr2 antagonist rs  (MedChemExpress)
93
MedChemExpress ccr2 antagonist rs
Ccr2 Antagonist Rs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccr2 antagonist rs/product/MedChemExpress
Average 93 stars, based on 1 article reviews
ccr2 antagonist rs - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
rs 504 393  (MedChemExpress)
93
MedChemExpress rs 504 393
Rs 504 393, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rs 504 393/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rs 504 393 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
rs504393  (MedChemExpress)
93
MedChemExpress rs504393
CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, <t>RS504393,</t> once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).
Rs504393, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rs504393/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rs504393 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
rs-504393  (Tocris)
90
Tocris rs-504393
CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, <t>RS504393,</t> once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).
Rs 504393, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rs-504393/product/Tocris
Average 90 stars, based on 1 article reviews
rs-504393 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
rs5043939  (MedChemExpress)
93
MedChemExpress rs5043939
CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, <t>RS504393,</t> once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).
Rs5043939, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rs5043939/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rs5043939 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
rs 504393  (MedChemExpress)
93
MedChemExpress rs 504393
CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, <t>RS504393,</t> once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).
Rs 504393, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rs 504393/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rs 504393 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
ap 1 inhibitor  (MedChemExpress)
93
MedChemExpress ap 1 inhibitor
CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, <t>RS504393,</t> once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).
Ap 1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ap 1 inhibitor/product/MedChemExpress
Average 93 stars, based on 1 article reviews
ap 1 inhibitor - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier

Image Search Results


CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, RS504393, once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).

Journal: Journal of Advanced Research

Article Title: The fatty acid receptor CD36 promotes macrophage infiltration via p110γ signaling to stimulate metastasis

doi: 10.1016/j.jare.2024.10.006

Figure Lengend Snippet: CD36 mediates the recruitment of macrophages through CCL2/CCR2 axis. A, The mRNA levels of chemokines in normal liver or LLC metastatic liver measured by RT-PCR (n = 4). c p < 0.05, b p < 0.01, a p < 0.001 vs normal liver. B, C, The mRNA levels of chemokines (B) and chemokine receptors (C) in tumor cells, BMDMs, CD11b + myeloid cells and blood monocytes (n = 4–6). c p < 0.05, b p < 0.01, a p < 0.001 vs the LLC group. D, E, The mRNA levels of Ccl2 or Mcsf (D) and their receptor Ccr2 or Csf1r (E) were measured in WT and Cd36 MKO mice with liver metastasis by RT-PCR (n = 5–6). F, G, The Ccr2 or Csf1r gene expression in WT and Cd36 -/- BMDMs (F), or in NC and CD36 OE THP-1 cells (G) cultured with TCM (n = 4–6). H, I, The MFI of CCR2 was measured in macrophages (H) and monocytes (I) isolated from metastatic liver tumors of WT and Cd36 MKO mice (n = 5). J, Migration assay was performed in WT or Cd36 -/- BMDMs treated with or without CCL2 or MCSF (n = 5). K-O, WT (n = 5) and Cd36 MKO (n = 5) mice were injected with LLC cells, following intraperitoneal injection of CCR2 inhibitor, RS504393, once a day from the 4th day to 14th day. HE-stained liver tissues along with the quantification of tumor area from WT and Cd36 MKO mice after treated with RS504393 (K, M, n = 3). F4/80-stained metastatic liver tissues from WT and Cd36 MKO mice after treated with RS504393 (L, M, n = 5). TSNE analysis of CD45 + cells isolated from the liver based on FCM (N). The percentage of indicated cells was measured (O, n = 5). Values for n represent biologically independent samples. Values for n represent biologically independent samples. Data are presented as mean ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 vs the control group; # p < 0.01, ## p < 0.01, and ### p < 0.001 vs the WT group. Unpaired two-tailed t -test (A, D-J), Unpaired two-tailed t -test with Mean-Whitney test (O) and ANOVA (B, C, M).

Article Snippet: For the treatment group, mice were individually treated with RS504393 (5 mg/kg, i.p., #HY-15418, MedChemExpress, Princeton, NJ, USA) or AS252424 (10 mg/kg, i.p., #HY-13532, MedchemExpress) once a day for 10 days, while the control group was given vehicle instead.

Techniques: Reverse Transcription Polymerase Chain Reaction, Gene Expression, Cell Culture, Isolation, Migration, Injection, Staining, Control, Two Tailed Test